AASraw waxay soo saartaa budada NMN iyo NRC tiro badan!

TAK-438

Rating: Category:

TAK438, oo sidoo kale loo yaqaan Vonoprazan Fumarate, waa daawo cusub oo lagu daaweynayo cudurada la xiriira aashitada iyadoo la adeegsanayo qaab cusub oo ficil ah oo loo yaqaan 'potassium-competitive acid blockers' (P-CABs) kaas oo si tartiib tartiib ah u xakameynaya ku xirnaanta ion-ka loo yaqaan 'H +, K + -ATPase ( sidoo kale loo yaqaan 'proton pump') talaabada ugu dambeysa ee dheecaanka acid gastric ee unugyada parietal gastric, wuxuu xakameynayaa dheecaanka acid gastric. Waxay bixisaa saameyn xoog leh oo joogto ah oo soo noqnoqota.

Product Description

Astaamaha Aasaasiga ah

Product Name Budada TAK-438
CAS Number 1260141-27-2
Formula kelli C21H20FN3O6S
Miisaanka Nooca 461.46
Isku mid ahaanshaha Vonoprazan Fumarate;
Budada TAK-438;
1260141-27-2;
Vonoprazan fumurate;
TAK438.
Imaanshaha Caddaan cad oo budada ah
Kaydinta iyo Isticmaalka Qalalan, madow iyo 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo) ama -20 C muddo dheer (bilo illaa sannado).

 

TAK-438 Sharaxaadda budada

TAK438, oo sidoo kale loo yaqaan Vonoprazan Fumarate, waa daawo cusub oo lagu daaweynayo cudurada la xiriira aashitada iyadoo la adeegsanayo qaab cusub oo ficil ah oo loo yaqaan 'potassium-competitive acid blockers' (P-CABs) kaas oo si tartiib tartiib ah u xakameynaya ku xirnaanta ion-ka loo yaqaan 'H +, K + -ATPase ( sidoo kale loo yaqaan 'proton pump') talaabada ugu dambeysa ee dheecaanka acid gastric ee unugyada parietal gastric, wuxuu xakameynayaa dheecaanka acid gastric. Waxay bixisaa saameyn xoog leh oo joogto ah oo soo noqnoqota.

Qanjidhada caloosha dhaqameed, daaweynta budada TAK-438 waxay dhalisay ka hortag sameynta aashitada oo sii dheeraatay. Saamaynta xakamaynta ee budada TAK-438 ee dheecaanka aashitada ayaa umuuqatay inuu laxiriira jir ahaanshaha unugyada caloosha.

 

Budada TAK-438 Mashruuca Hawlaha

Budada TAK-438 (Vonoprazan fumarate) waa soosaaris pyrole iyo potassium-tartame acid acid (P-CAB) kaas oo si tartan leh u xannibaya goobta ku xiran potassium ee caloosha H (+), K (+) - ATPase, enzyme muhiim ah habka dheecaanka aashitada caloosha. Xaruntu waxay ku urursan kartaa bay'ada aashitada waana inay bixisaa muddo dheer oo ka hortag ah sababtoo ah pKa alkaline ah 9.06

Qanjidhada caloosha dhaqameed, daaweynta budada TAK-438 waxay dhalisay ka hortag sameynta aashitada oo sii dheeraatay. Saamaynta xakamaynta ee budada TAK-438 ee dheecaanka aashitada ayaa umuuqatay inuu laxiriira jir ahaanshaha unugyada caloosha.

 

TAK-438 Codsiga budada ah

Budada TAK-438 (Vonoprazan fumarate ama Vonoprazan) waa daawo cusub oo lagu daaweynayo cudurada la xiriira aashitada iyadoo la adeegsanayo qaab cusub oo ficil ah oo loo yaqaan 'potassium-competitive acid blockers' (P-CABs) kaas oo si tartiib tartiib ah u xakameynaya ku xirnaanta ion potassium ee H +, K + - ATPase (oo sidoo kale loo yaqaan proton pump) tallaabada ugu dambeysa ee dheecaanka acid gastric ee unugyada parietal gastric. Daawada waxaa laga ansixiyay Japan daaweynta cudurada la xiriira aashitada, oo ay kujiraan ulcer, duodenal ulcer, reflux esophagitis iyo Adjunct ilaa ciribtirka Helicobacter pylori marka laga hadlayo Helicobacter pylori gastritis.

 

TAK-438 budada Waxyeellooyinka & Digniinta

Saameynaha caadiga ah waxaa ka mid ah:

▪ shuban,

Lallabbo iyo matag,

▪ calool fadhiga,

▪ calool xanuun,

Rash finan maqaarka ah,

▪ laab xanuun

 

Kuwani dhammaantood maahan waxyeellooyinka suurtagalka ah ee TAK438. Wixii macluumaad dheeraad ah, weydii dhakhtarkaaga ama farmashiistahaaga. Wac dhakhtarkaaga si aad uga hesho talo caafimaad wixii ku saabsan dhibaatooyinka soo raaca. Waxaad ku soo wargelin kartaa waxyeellooyinkaaga FDA 1-800-FDA-1088.

 

Tixraaca

[1] Arikawa Y, Nishida H, Kurasawa O, Hasuoka A, Hirase K, Inatomi N, Hori Y, Matsukawa J, Imanishi A, Kondo M, Tarui N, Hamada T, Takagi T, Takeuchi T, Kajino M. Discovery of 1-5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e fumarate (budada TAK-438) oo ah tartan potassium ah Xidha acid (P-CAB). J Med Chem. 2012 Meey 10; 55 (9): 4446-56. doi: 10.1021 / jm300318t. Epub 2012 Apr 30. PubMed PMID: 22512618.

[2] Kondo M, Kawamoto M, Hasuoka A, Kajino M, Inatomi N, Tarui N. Baadhitaan aad u sareeya oo lagu baaro dadka kahortaga aashitada ku-tartameysa. J Shaashadda Biomol. 2012 Febraayo; 17 (2): 177-82. doi: 10.1177 / 1087057111421004. Epub 2011 Sep 22. PubMed PMID: 21940711.

[3] Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G. Astaamaynta aallad-cusbooneysi-tartameedka aashitada cusub ee caloosha H, K-ATPase, 1- [5- (2- fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (budada TAK-438). J Pharmacol Exp Ther. 2011 Nofeembar; 339 (2): 412-20. doi: 10.1124 / jpet.111.185314. Epub 2011 Agoosto 9. PubMed PMID: 21828261; PubMed Bartamaha PMCID: PMC3199995.

[4] Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. Daraasad isbarbardhigaya saameynta daawada antisecretory ee budada TAK-438, sheeko xariirka aashitada potassium-tartame ee cusub, oo leh lansoprazole ee xoolaha J Pharmacol Exp Ther. Juun 2011; 337 (3): 797-804. doi: 10.1124 / jpet.111.179556. Epub 2011 Mar 16. La daabacay PMID: 21411494.

[5] Matsukawa J, Hori Y, Nishida H, Kajino M, Inatomi N. Daraasad isbarbardhig ah oo ku saabsan qaababka ficil ee budada TAK-438, sheeko xiraha aashitada potassium-tartame, iyo lansoprazole ee qanjidhada bakaylaha asaasiga ah. Farmashiyaha Biochem. 2011 Meey 1; 81 (9): 1145-51. doi: 10.1016 / j.bcp.2011.02.009. Epub 2011 Mar 1. PubMed PMID: 21371447.

[6] Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N. 1- [5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (budada TAK-438), oo ah sheeko ugub ah oo awood u leh ka-hortagga aashitada potassium ee daaweynta cudurada la xiriira aashitada. J Pharmacol Exp Ther. 2010 Oktoobar; 335 (1): 231-8. doi: 10.1124 / jpet.110.170274. Epub 2010 Jul 12. La daabacay PMID: 20624992.