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Sunitinib Malate

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Sunitinib wuxuu joojiyaa calaamadaha gacanta isagoo bartilmaameedsanaya dhowr daaweeyn tyrosine kinases (RTKs) Kuwaani waxaa ka mid ah dhammaan kuwa soo dhaweynaya ee loogu talagalay cunsuriyada hormoonka dhalmada (PDGF-Rs) iyo soo dhaweynta maqaarka xididada jirka ee xididada dhiigga (VEGFRs), oo door ka ciyaara labada buro angiogenesis iyo unugyada burooyinka. batay.

Product Description

Astaamaha aasaasiga ahcs

Product Name Budada Sunitinib Malate
CAS Number 341031-54-7
Formula kelli C22H27FN4O2
Mass molar 398.474
Isku mid ahaanshaha 557795-19-4;

Sentent;

Sunitinib budada ah;

SU11248

Imaanshaha budo White
Kaydinta iyo Isticmaalka Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan.

 

Sharaxa budada Sunitinib Malate

Sunitinib (oo loo suuq geeyay sida Sutent by Pfizer, horayna loogu yaqiinay SU11248) waa hadal afka ah, yar-yar, iskudhac wax-qabad leh oo badan oo loo yaqaan 'tyrosine kinase (RTK)' kaas oo ay ansixisay FDA si loogu daaweeyo kansarka kelyaha kelyaha (RCC) iyo imatinib buro-xanuun caloosha ku jira (GIST) Janaayo 26, 2006. Sunitinib wuxuu ahaa dawadii ugu horeysay ee kansarka isla mar loo ansixiyo laba tilmaamood oo kala duwan.

 

Mashruuca budada Sunitinib Malate

Sunitinib wuxuu joojiyaa calaamadaha gacanta isagoo bartilmaameedsanaya dhowr daaweeye tyrosine kinases (RTKs).

Kuwaas waxaa ka mid ah dhammaan kuwa soo-dhoweeyeyaasha ah ee loogu talagalay cunsur-soo-saarka platelet-ka (PDGF-Rs) iyo soo-saareyaasha koritaanka cuncunka xididdada xididdada dhiigga (VEGFRs), oo door ka ciyaara labada buro angiogenesis iyo kordhinta unugyada. Xakamaynta isku mar ee bartilmaameedyadani waxay markaa yareyneysaa vascularization-ka burooyinka waxayna kicineysaa unugyada kansarka apoptosis sidaas darteedna waxay keenaysaa yareynta burooyinka.

Sunitinib wuxuu kaloo joojiyaa CD117 (c-KIT), [2] receptor tyrosine kinase oo (marka si aan habooneyn udhaqaajiyo isbadalku) wado inta badan burooyinka unugyada caloosha iyo caloosha.Waxaa lagula taliyay inay noqoto daaweyn labaad oo loogu talagalay bukaanada burooyinkooda ay yeeshaan isbedel C-KIT oo ka dhigaya kuwo u adkaysta imatinib, ama kuwa aan u dulqaadan karin daroogada.

 

Sunitinib Malate Codsiga budada

 Burooyinka caloosha ku dhaca ee caloosha ku jira

Sida RCC, GIST guud ahaan kama jawaabo daaweynta kiimiko ee caadiga ah ama shucaaca. Imatinib wuxuu ahaa wakiilkii ugu horreeyay ee kansarka lagu caddeeyo inuu waxtar u leeyahay cudurka 'GIST metastatic' wuxuuna matalayay horumar weyn oo lagu daweynayo cudurkan dhifka ah laakiin dhibka badan.

 

 Meningioma

Sunitinib waxaa loo baranayaa daaweynta meningioma oo la xiriirta neurofibromatosis.

 

 Burooyinka Pancreatic neuroendocrine

Bishii Nofeembar 2010, Sutent wuxuu oggolaansho ka helay Guddiga Yurub ee daaweynta 'qanjirada aan la-beddeli karin ama metastatic, burooyinka qanjidhada qanjirada' neuroendocrine 'oo si fiican u kala duwan oo leh horumarka cudurka ee dadka waaweyn'.

 

 Kansarka unugyada kansarka

Sunitinib waxaa loo oggol yahay daaweynta metastatic RCC. Fursadaha kale ee daaweynta ee goobtani waa pazopanib (Votrient), sorafenib (Nexavar), temsirolimus (Torisel), interleukin-2 (Proleukin), everolimus (Afinitor), bevacizumab (Avastin), iyo aldesleukin.

 

Budada Sunitinib Malate Waxyeelada & Digniinta

Dhacdooyinka xun ee Sunitinib waxaa loo tixgeliyaa xoogaa la maareyn karo iyo dhacdooyinka dhacdooyinka xun ee xun ayaa hooseeya.

Dhacdooyinka xun ee ugu badan ee la xiriira daaweynta sunitinib waa daal, shuban, lallabbo, anorexia, dhiig kar, maqaarka oo midab jaalle noqda, falcelinta maqaarka lugta, iyo stomatitis. Daraasad ku-meel-gaadh ah xakamaynta wajiga III GIST, dhacdooyinka xun ee badanaa ku dhacay sunitinib marka loo eego placebo waxaa ka mid ah shuban, anorexia, maqaarka oo midab doorsooma, mucositis / stomatitis, asthenia, dhadhanka la beddelay, iyo calool istaagga.

Qiyaasta dhimista ayaa loo baahday 50% bukaanada wax ku bartay RCC si loo maareeyo sunta muhiimka ah ee wakiilkan.

Dhacdooyinka halista ah (darajada 3 ama 4) dhacdooyinka qallafsan waxay ku dhacaan ≤10% bukaannada waxaana ka mid ah dhiig-kar, daal, asthenia, shuban, iyo kiimiko ku daweynta loo yaqaan 'acral erythema'. Cilladaha aan caadiga ahayn ee shaybaarka ee laxiriira daaweynta sunitinib waxaa kamid ah lipase, amylase, neutrophils, lymphocytes, iyo platelet. Hypothyroidism iyo erythrocytosis dib loo celin karo ayaa sidoo kale lala xiriiriyay sunitinib.

 

Tixraaca

[1] Maamulka Cuntada iyo Dawooyinka ee Mareykanka (2006). "FDA waxay ansixineysaa daaweynta cusub ee kansarka caloosha iyo kilyaha".

[2] Hartmann JT, Kanz L (Noofambar 2008). "Sunitinib iyo hoos u dhigis timo xilliyeed sababtoo ah xannibaadda c-KIT ee ku meel gaarka ah". Armat Dermatol. 144 (11): 1525-6. doi: 10.1001 / archderm.144.11.1525. PMID 19015436. Waxaa asalka laga keydiyay 2011-07-25.

[3] Quek R, George S (Febraayo 2009). "Buro caloosha ku timaadda caloosha: guudmar caafimaad". Hematol. Oncol. Clin. Waqooyiga Am. 23 (1): 69-78, viii. doi: 10.1016 / j.hoc.2008.11.006. PMID 19248971.

[4] Blay JY, Reichardt P (Juun 2009). "Burooyinka caloosha ee caloosha ku jira ee horumarsan ee Yurub: dib u eegis lagu sameeyay talooyinka daaweynta ee la cusbooneysiiyay" Khabiirka Rev Anticancer Ther. 9 (6): 831-8. doi: 10.1586 / era.09.34. PMID 19496720. S2CID 23601578.

[5] Gan HK, Seruga B, Knox JJ (Juun 2009). "Sunitinib ee burooyinka adag". Khabiirka Opin Investig Mukhaadaraadka. 18 (6): 821–34. doi: 10.1517 / 13543780902980171. PMID 19453268. S2CID 25353839.

[6] "U qorida macluumaadka loogu talagalay Sutent (sunitinib malate powder)". Pfizer, Inc, New York NY.