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Spermidine Powder Sharaxaad

Budada Spermidine waa maaddo soo jiidasho leh waxayna hordhac u tahay shahwada. cuntooyin badan waxaa ku jira spermidine, sida boqoshaada, soybeans, lowska, iyo gaar ahaan jeermiga qamadiga.Spermidine waxaa laga helaa dhammaan dhirta iyo xayawaanka iyo ku dhawaad ​​unug kasta oo jirkaaga ah. Jidhkeenna, waxay ka imaan kartaa cuntada la cunay - oo lagu soo dhex daray microbiome -ka mindhicirka ama lagu dhex daray unugyada.Bermperine budada ayaa door muhiim ah ka leh noolaha, sida dadka iyo xitaa dhirta. Mid ka mid ah shaqooyinka ugu waaweyn uguna qotada dheer ee spermidine, oo ay hawlaha kale ka soo jeedaan, ayaa ah kartida lagaga hortagi karo gabowga iyo kor u qaadista autophagy.

Habka Spermidine ee Waxqabadka

Spermidine waa polyamine aliphatic ah. Spermidine synthase (SPDS) ayaa ka soo saarta samayskeeda putrescine. Waa horudhaca polyaminesyada kale, sida shahwada iyo isomer -dhismeedkeeda, shahwada kulul.

Spermidine waa wakiilka cimriga dheer ee naasleyda sababo la xiriira farsamooyin kala duwan oo waxqabad, farsamooyinkan ayaa hadda bilaabaya in la fahmo. Autophagy waa farsamada ugu weyn ee heerka molikuyuulka, laakiin waxaa la helay caddayn farsamooyin kale, oo ay ku jiraan bararka oo yaraaday, dheef -shiid kiimikaad, iyo nidaaminta koritaanka unugyada, fiditaanka, iyo dhimashada.

Faa'iidooyinka Powder Spermidine

Spermidine waxay lagama maarmaan u tahay habka cusboonaysiinta unugyada. Marka ay unugyada duugga ahi dhintaan, unugyo kale iyaga ayaa hilib dila oo isticmaala molecules si ay u dhisaan unugyo cusub. Markaan sii gabowno, heerka dabiiciga ah ee shahwada shahwada ee jirkeena ayaa hoos u dhici doonta, taas oo yareyneysa awoodda unugyada inay is -cusboonaysiiyaan oo is -hagaajiyaan.

Spermidine ayaa sidoo kale la muujiyey inay yareyso halista noocyada kansarka qaarkood, haddii la qaato muddo dheer oo ku filan, waxay sii dheerayn kartaa nolosha. Waxaana laga yaabaa inay wanaajiso ilaalinta tallaalka dadka waayeelka ah.

Iyo spermidine waxay kaalin muhiim ah ka qaadataa joogteynta xuubka unugyada iyo xakameynta pH -ka iyo mugga intracellular. Daraasaduhu waxay kaloo muujiyeen inay yarayn karto halista cudurrada wadnaha iyo hagaajinta garashada. Spermidine waxay leedahay saamayn neuroprotective ah dhaawaca neuronal -ka ee ay keento barar, ischemia iyo cadaadiska oksaydhka.

Saamaynta Spermidine Powder

Sababo la xiriira hababka kala duwan ee ficilka, spermidine waa wakiil cimri dherer u ah naasleyda, oo ay ku jiraan caabuq yaraaday, dheef -shiid kiimikaad, iyo nidaaminta koritaanka unugyada, fiditaanka, iyo dhimashada. Spermidine waxay ka hortagi kartaa fibrosis beerka iyo kansarka hepatocellular oo ka mid ah sababaha ugu badan ee keena kansarka beerka. Waxaa caadi ahaan loo adeegsadaa kaabisyo kuwaas oo, marka la qaato, si joogto ah, saamayn weyn ku yeelan kara cimri dhererka.

Sharaxaada budada ee Spermidine trihydrochloride

Budada Spermidine trihydrochloride sidoo kale waa polyamine ka hortagta neuronal nitric oxide synthase (nNOS) waxayna xidhaa oo soo daadisaa DNA. Waxaa laga yaabaa in loo isticmaalo in lagu nadiifiyo borotiinka ku xidhan DNA. Intaa waxaa sii dheer, spermidine waxay kicisaa waxqabadka T4 polynucleotide kinase. Waxay ku lug leedahay koritaanka, horumarka, iyo jawaab -celinta walaaca ee dhirta.

Spermidine trihydrochloride Mechanism of Action

Spermidine trihydrochloride waa polyamine dabiici ah oo laga soo saaray putrescine iyo decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, waa soo-saare autophagy cusub oo si xun u beddelaya N-methyl-d-aspartate (NMDA).

Wuxuu ku xiraa goobta modulatory-ka polyamine ee soo-dhoweeyaha NMDA waxaana lagu tilmaamay inuu yahay agonist ku saleysan kartideeda si kor loogu qaado isku xirnaanta [3H] -MK801.

Codsiga budada Spermidine trihydrochloride

Spermidine trihydrochloride ayaa loo isticmaalay astaamaha fourier transformer spectroscopy (FTIR) iyo cabbirrada suurtagalka ah.

Spermidine hydrochloride waxaa laga helaa si dabiici ah oo lagama maarmaan u ah koritaanka unugyada; Waxaa badanaa loo adeegsadaa sidii aalad cilmi -baaris biochemical; Spermidine hydrochloride waa isku -darka polyamine, C7H22Cl3N3, oo laga helo ribosomes iyo unugyo nool oo leh shaqooyin dheef -shiid kiimikaad oo kala duwan gudaha noolaha.

Saameynta Spermidine trihydrochloride Powder

Budada Spermidine trihydrochloride waxay ka hortagtaa neuronal nitric oxide synthase (nNOS). Wuxuu xidhaa oo soo dedejiyaa DNA; Budada Spermidine trihydrochloride waxaa laga yaabaa in loo isticmaalo nadiifinta DNA -ga isku xira borotiinka waxayna jadwalaysaa waxqabadka T4 polynucleotide kinase.

Xagee laga Iibsadaa budada Spermidine ee Jumlada ah?

AASraw waa soo -saare iyo soo -saare budada shahwada weyn oo iib ah. Haddii aad rabto inaad ku iibsato budada shahwada si aad u tiro badan, fadlan si toos ah noogu soo dir baadhitaanka.

Tixraaca:

[1] Qaamuuska Dhaxalka Ameerika La Soo Celiyey 2014-11-18.
[2] Minois, Nadège (28 Janaayo 2014). "Aasaaska Molecular ee Saamaynta" Ka-hortagga Gabowga "ee Spermidine iyo Polyamines-ka kale ee Dabiiciga ah-Dib-u-eegis Yar-yar". Gerontology. 60 (4): 319–326. doi: 10.1159/000356748. PMID 24481223.
[3] Madeo F, Eisenberg T, Pietrocola F, Kroemer G (2018). "Spermidine ee caafimaadka iyo cudurrada". Sayniska. 359 (6374): eaan2788. doi: 10.1126/science.aan2788. PMID 29371440.
[4] [4] Ramot, Yuval; Tiede, Stephan; Bíró, Tamás; Abuu Bakar, Mohd Hilmi; Sugawara, Koji; Philpott, Michael P .; Harrison, Wesley; Pietilä, Marko; Paus, Ralf (27 Luulyo 2011). "Spermidine waxay dhiirrigelisaa Kobaca Timaha Aadanaha waana Qaab -dhismeedka Novel ee Hawlaha Unugyada Jirrada Epithelial Human". KA BADAN HAL. 6 (7): e22564. doi: 10.1371/journal.pone.0022564. ISSN 1932-6203. PMC 3144892. PMID 21818338.
[5] Munir et al (1993) Polyamines waxay wax ka beddelaan saameynta neerfaha ee NMDA ee vivo. Maskaxda. 616 163 PMID: 8358608.
[6] Williams et al. Mol.Pharmacol. 1989 3 PMID: 801

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