IDFP

AASraw waxaa ku jira awoodda wax soo saar iyo karti wax-soo-saarka laga bilaabo gram ilaa nidaamka xajmiga ah ee IDFP (615250-02-7), iyadoo la raacayo nidaamka CGMP iyo nidaamka xakamaynta tayada la socon karo.

IDFP waa unug jirka ah oo ka kooban organophosphorus oo si macquul ah u xakameynaya MAGL iyo FAAH oo leh qiimayaasha IC50 ee 0.8 iyo 3 nM. 1 10 mg / kg, IDFP waxay sare u qaadaysaa heerarka maskaxda ee 2-AG iyo AEA in ka badan 10-laab, oo hoos u dhigta heerarka sunta arachidon dhererka isku midka ah. Xanuunada xannuun-joojinta, 2-arachidonoyl glycerol (2-AG) iyo arachidonoyl ethanolamide (AEA), waa lipids firfircoon oo xakameynaya hawlaha kala duwan ee dareemayaasha iyo dheef-shiid kiimikaadka iyadoo la adeegsanayo soo-saarka xasaasiyadaha cannabinoid, cannabinoid dhexe (CB1) iyo canjabinoid (CB2). Lacagtada monoacylglycerol (MAGL) iyo amidhydrolase (FAAH) waxay ku shaqeyneysaa 2-AG iyo AEA siday u kala horreeyaan, sidaas darted joojinta shaqadooda bayoolojiga ah.

Product Description

Video IDFP


I.IDFP Calaamadaha aasaasiga ah:

Name: IDFP
CAS: 615250-02-7
Nooca Molecular: C15H32FO2P
Miisaankani waa: 294.391
Dhibcaha Biyaha:
Kaydinta Nabadgelyada: -20 ° C
Color:


II. Wareegga IDFP

1.Names:

Magacyada kiimikada: ISOPROPYL DODECYLFLUOROPHOSPHONATE
Isku mid ahaan:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID

2. Isticmaalka IDFP:

IDFP waa unug jirka ah oo jidhka ka mid ah oo la xidhiidha wakiilka xanuunka sarin. Like sarin, IDFP waa inhibitor ah karin, waayo, tiro ka mid ah ensaymes kala duwan sida caadiga ah u adeegaan si ay u burburiyaan neurotransmitters, si kastaba ha ahaatee silsiladda alkyl dheer IDFP ka dhigaysa in ay si weyn oo taharyar junuud inhibitor ah acetylcholinesterase (xanuun), la IC50 ah oo kaliya 6300nM, halka waa inhibitor a awood laba ensaymes monoacylglycerol lipase (MAGL), enzyme koowaad ka masuul ah xaalufinta ku 2-arachidonoylglycerol endocannabinoid (2-AG), iyo dufan hydrolase amide acid (FAAH), enzyme hoose oo hoos u anandamide kale ugu weyn endocannabinoid . IC50 ee IDFP waa 0.8nM ee MAGL, iyo 3.0nM ee FAAH. Xakamaynta labadan enzymes waxay keenaysaa heerar korodhsan oo ah heerarka labadaba anandamide iyo 2-AG oo maskaxda ku jirta, taas oo keentay saameynta cannabinoid iyo saameynta dabeecada caadiga ah ee cannabinoid ee daraasaadka xayawaanka, iyada oo awooddeeda aysan laheyn AChE micnaheedu waa in aan la ogeyn calaamadaha cudurka cholinergic. "1] [2] Inkasta oo qaabkeeda kiimikada la midka ah ee loo adeegsado xayawaanka la mamnuucay, silsilada dheer ee alfuuriga ah ee IDFP waxay sababtaa inay ka baxdo qeexitaanka" kiimikada sunta ah "ee hoos imaanaya Heshiiska Hubka Kiimikada [3] iyo tan iyo sidoo kale ma muujin kartid xoogga AChE xoogga ah ee xeryaha loo yaqaan organophosphorus, IDFP maaha mid la mid ah xakamaynta sharciga ee adag.

3.Waa maxay qiyaasta IDFP?

Kaydinta muddada dheer, waxaan ku talineynaa in IDFP la keydiyo sida ku jirta -20 ℃. Waa inay ahaato mid degan ugu yaraan hal sano.
IDFP waxaa loo bixiyaa xal sida methyl acetate. Si aad u beddesho xalka, si fudud uumi gashiga methyl acetate iyadoo la raacayo socodka qulqulka ah ee nitrogenand isla markiiba ku darso xalka doomaha. Kuwa sida etanol, DMSO, iyo dimethyl formamide oo lagu nadiifiyo gaas geel ah ayaa loo isticmaali karaa. Xakamaynta IDFP ee ku jira dareerayaasha kuwan waa qiyaastii 10mg / ml.
Haddii xalalka aqueous stock-ka loo baahan yahay tijaabooyinka bayoolajiga, waxay si fiican ugu diyaargaroobi karaan adoo isticmaalaya qasacadeyaal dabiiciga ah oo ku jira maadada aqueous ama salinein isotonic. Fiiri in qaddarka haraaga ah ee hanti-bixiyuhu uu yahay mid aan muhiim ahayn, maadaama ay dareerayaasha dabiiciga ahi yeelan karaan saameyn nafsi ah oo leh heerarka hooseeya. laguma talin inaad kaydiso xalinta aqueous in ka badan hal maalin.

4.How IDFP ma shaqeysaa?

IDFP waa inhibitor ah karin, waayo, tiro ka mid ah ensaymes kala duwan sida caadiga ah u adeegaan si ay u burburiyaan neurotransmitters, si kastaba ha ahaatee silsiladda alkyl dheer IDFP dhigaysa itdramatically taagta daran sida inhibitor ah acetylcholinesterase (xanuun), halka ay tahay inhibitor a awood laba ensaymes monoacylglycerol lipase ( MAGL), enzyme aasaasiga ah ee mas'uulka ka ah xakameynta endocannabinoid 2-arachidonoylglycerol (2-AG), iyo hidde-nadiifinta ambalaan (fatah acid amide hydrolase) (FAAH), enzyming primary kaas oo hoos u dhigta kale anandamide anaendocannabinoid. Qalabka jirheerka ah ee si habsami leh u difaacaya MAGL iyo FAAH oo leh qiimaha IC50 ee 0.8 iyo 3 nM siday u kala horreeyaan. 1 10 mg / kg, IDFP waxay sare u qaadaysaa heerarka maskaxda ee 2-AG iyo AEA in ka badan 10-laab, waxayna hoos u dhigtaa heerarka arachidone acid by 10-laab.

5.Warning:

Badeecadani maahan adeegsiga aadanaha ama kuwa caafimaadka xoolaha, digniino badan ayaa weli ku jira baaritaan. Ka fogow taabashada tooska ah ee maqaarka, indhaha, mareenka neefta, raaxo la'aan, wac dhakhtarkaaga isla markiiba.

6.IDFP Khamri cadi ah:

Si aad u dalbato 10grams.
Baadhitaanka xaddiga caadiga ah (1kg gudaheeda) waxaa loo diri karaa saacadaha 12 kadib bixinta.
Amar wayn ayaa loo diri karaa 3 maalmaha shaqada ka dib bixinta.

7.IDFP Rooti Khafiif ah:

Si aad u ogaato faahfaahinta macaamiisha (CSR) faahfaahinta, tixraacaaga.

Suuqa 8.IDFP:

Si loo bixiyo mustaqbalka soo socda.

9.Doomaha IDFP Wax Saameyn Ku Saabsan

Xakamaynta caanaha, oo loo tixgeliyey muhiimadda ay leedahay qiyaasta milixda iyo dheellitirka biyaha iyo xakamaynta dhiigga ee muddada dheer, ayaa lagu kordhiyay anandamide iyo laba ka mid ah istiraatiijiyadaha waaweyn ee metabolizing, cyclooxygenase-2 (COX-2) iyo hidde-dufan amase hidde ah (FAAH) . Faleebo of anandamide (15, 30, iyo 60 nmol · min-1 · kg-1) galay medulla ee kelyaha ee jiirka C57BL / 6J dhiiri diuresis iyo Digo cusbo in a Cox-2- laakiin ma hab Cox-1 ku tiirsan. Si loo go'aamiyo in endocannabinoids endocannabinoids ee xuubka medulla xayeysiin karaan saameyn la mid ah, saameynta ay intramedullary isopropyl dodecyl fluorophosphate (IDFP), taasoo horjoogsatay labada hydrolases endocannabinoid weyn, ayaa la darsay. Daaweynta IDFP waxay kordhay xaddiga kaadi-keenidda iyo sifeynta sodium COX-2- laakiin ma ahan habka COX-1. Lamaandheysi ama IDFP wax saameyn ah u lahayn sifooyinka glomerular. Midkoodna systemic (0.625 mg · kg-1 · 30 min-1 iv) mana intramedullary (15 nmol · min-1 · kg-1 · 30 min-1) pretreatment IDFP hor anandamide intramedullary (nmol 15-30 · min-1 · kg-1) Dhibaatooyinka adag ee la xannibay ee anandamide, oo tilmaamaya in hiddo-galeetada anandamide aysan muhiim ugu ahayn saameynta duriinka. Barnaamijka IDFP ee saamaynta ku leh ayaa saameyn ku yeeshay socodka dhiigga ee kelyaha laakiin wuxuu dhiirrigeliyay socodka dhiigga ee dhiigga. Saameynta IDFP ku saabsan heerka socodka kaadida iyo socodka dhiigga ee medullary waxay ahaayeen kuwo ku tiirsan FAAH iyaga oo muujinaya isticmaalka jiirka jiirka ee FAAH. Falanqaynta uruureen mouse PGE2 kaadida by HPLC-electrospray tusmo ionization spectrometry mass muujisay in daaweyn IDFP hoos PGE2 kaadida xogta waxay la door ah FAAH iyo anandamide qoomiyadda sii marayo metabolite a Cox-2 ku tiirsan si ay sharciyaynta diuresis iyo cusbo Digo ee mousekidney.


III. IDFP HNMR

Waxaanu nahay saabuunta budada loo yaqaan "Aprepitant powdered", Badeecada xayawaanka ee iibka ah, budada qalalan (170729-80-3) hplc = 98% | AASraw R & D Reagents


IV. Sida loo soo iibsado IDFP ka timaada AASraw?

1.To nagula soo xiriir emailkayaganidaamka weydiinta, ama skype onlinewakiil adeegga macaamiisha (CSR).
2.To nuujinta tirada iyo cinwaanka aad weydiisatay.
3.Our CSR waxay ku siin doontaa qiimaha, qiimaha bixinta, nambarka raadinta, siyaabaha gudbinta iyo taariikhda la qiyaasi karo (ETA).
4.Payment ayaa la sameeyaa, alaabtana waxaa loo diri doonaa saacadaha 12 (Si loo dalbado 10kg).
5.Gudbiyadu waxay heleen oo dhiibaan faallooyin.


Tijaabi bartaada sheyga ee aad jeceshahay:

Sida loo isticmaalo Clinbuterol miisaanka lumitaanka Waa maxay budada nandrolone loo isticmaalo faa'iidooyinka / nandrolone?


Faahfaahin dheeraad ah oo ku saabsan alaabooyinka la xiriirasoo dhawow inaad gujiso halkan.


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