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Dolastatin 10 (110417-88-4)

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SKU: 110417-88-4. Category:

AASraw waxaa la socda awoodda wax soo saarka iyo wax soo saarka laga bilaabo gram ilaa nidaamka qiyaasta ah ee Dolastatin 10 (CAS 110417-88-4), iyada oo la raacayo nidaamka CGMP iyo nidaamka xakamaynta tayada la socon karo.

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Dolastatin 10 video


I.Dolastatin 10 Calaamadaha aasaasiga ah:

Name: Dolastatin 10
CAS: 110417-88-4
Formula kelli: C42H68N6O6S
Miisaankani waa: 785.09g / mol
Dhibcaha Biyaha: 94-95oC
Kaydinta Nabadgelyada: Ku kaydi meel qaboow oo qallalan oo 0 - 4 ℃ muddo gaaban (maalmo ilaa toddobaad) ama -57 ℃ muddo dheer (bilo illaa sanado)
Color: Caddaan si cad-cadaan ah


II. Dolastatin 10 (110417-88-4) isticmaalka wareegga antitumor

1. Magacyada:

Magaca kiimikada:
Dolastatin 10 (CAS 110417-88-4), Dolastatin-10, Neuro_000215, CCRIS 7310, CID100208, NSC376128,NSC 376128, C11280, L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-

2.Dolastatin 10 Isticmaal:

Ujeeddo: Cilmi-baariste cilmi-baaristu wuxuu baaray wax-qabadka iyo sun-beelka dawada anti-microtubule dolastatin-10 ee bukaanka qaba kansarka naasaha oo sare.

Hababka: 21 bukaan oo qaba kansarka naasaha ee la cabiray waxaa lagu daaweeyay dolastatin-10 qiyaasta xNUMX mcg / m400 adigoo isticmaalaya xididada xididdada marxalad kasta 2.

Natiijooyinka: Mid ka mid ah bukaanka 21 (5%; 95% CI: 0-24%) waxay gaareen qayb ka mid ah xasaasiyadda qaybta 113. Afar bukaanno ayaa ku sugnaa xanuun xasilloon oo dhexdhexaad ah maalmaha 87. Bukaan-jiifku wuxuu helay dhexdhexaad laba wareeg ah oo ah dolastatin-10. Cudurka Hematologic toxicity wuxuu ahaa mid dhexdhexaad ah, iyada oo bukaanada 8 ay kobcinayaan heerka 4 neutropenia, iyo 5 oo leh darajada 3 neutropenia; hal darajo 3 febrile neutropenia ayaa la arkay. Xaaladahan 3 iyo 4 neutropenia ayaa la kulmay 36% ee wareegyada daaweynta. Saamayn aan sambabada aheyn oo aan caadi ahayn.

Gabagabo: Inkastoo profile of toxic ah ee dolastatin-10 ahaa mid la aqbali karo, waxay leedahay wax yar oo firfircoon ee daraasaddan horumarka kansarka naasaha.

In Vitro: Dolastatin 10 waa pentapeptide gaar ah oo ka soo go'ay hareeraha Dolabella auricularia. Waxaa la ogaaday in xogta ku jirta fitamiinada ay aad u la mid yihiin kuwa Dolastatin 10 iyo Auristatin PE, mid kasta oo ka mid ah qiimaha GI50 ee 10-5-10-6 μg / mL (10-2-10-3 nM) minipanel ee khadadka unugyada aadanaha. Isku-xirka antibody-drug conjugate (ADC) wuxuu ka kooban yahay antibody monoclonal monoclonal antiocycle cAC30 oo ku xiran wakiilka cytotoxic monomethyl auristatin E (MMAE), oo ah analogetic of tubulin polymerization inhibitor Dolastatin 10 (10-110417-88).

3.Warning on Dolastatin 10

Badeecadani waxay u adeegsaneysaa isticmaalka cilmi-baarista oo keliya, ee aan loogu talagelin isticmaalka dadka ama caafimaadka xoolaha.

Si aad u heshid xakameyn sare, fadlan diirada tuubada 37 ℃ oo ruxin bacda ultrasonic mudo ah. Qalabka xakamaynta waxaa lagu kaydin karaa hoos -20 ℃ dhawr bilood.

4. Talooyin dheeraad ah:

Dhiigga Dastuurka 10
Isugeynta Total Dolestatin 10 (110417-88-4) waxaa lagu dhammeystirey iyada oo la dhisayey soo saarid wanaagsan oo ah laba qaybood oo muhiim ah oo amino acid ah, Dil (6) iyo Dap (11), iyo kaddibna xajineyn shan qaybood oo amino acid ah oo ka yimid C-terminal .

Qalabaynta iyo Qiimeynta Dolastatin 10 Analogs Containing Heteroatoms oo ku taala Amino Acid Side Silsilado.
Xaaladaha isdabajooga ah ee dolastatin 10 ayaa aad u daneynaya kansarka sababtoo ah awooddooda ku jirta fayodhowrka iyo adeegsigooda sida mushaharka lagu qaato daawooyinka antibody (ADCs). Isbeddelka xawaaladda 10 ee ugu muhiimsan waxa uu inta badan diirada saaray isbeddellada P1, N-terminus, iyo P5, C-terminus, oo leh fiiro gaar ah u leh sub-aagga P2.

Baaritaanka gacanta, Dolastatin 10 (110417-88-4) wuxuu muujinayaa dhaqdhaqaaqa ka yimaada qaar ka mid ah caleemo-bini'aadamka, lymphoma iyo xarumaha unugyada adag (sida OVCAR-3 iyo NSCLC) oo leh qiimooyin IC50 oo ka bilaabma 0.1nM ilaa 10nM. Waxaa iminka lagu tijaabiyaa tijaabooyinka caafimaadka.


III. Dolastatin 10 (110417-88-4) HCML

Waxaanu nahay saabuunta budada loo yaqaan "Aprepitant powdered", Badeecada xayawaanka ee iibka ah, budada qalalan (170729-80-3) hplc = 98% | AASraw R & D Reagents


IV. Sida loo iibsado Dolastatin 10 ka soo AASraw?

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U DIYAAR-GARASHADA iyo kala-tagga:

Qalabkan waxaa loo iibiyaa Adeegsiga Cilmi-baarista Kaliya. Shuruuda Iibka ayaa la Codeynayaa. Loogu talagalay Isticmaalidda Aadanaha, ama Daawooyinka, Caafimaadka Xoolaha, ama Isticmaalka Guryaha.