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Allopregnanolone

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Allopregnanolone, oo sidoo kale loo yaqaan Sepranolone iyo Isopregnanolone, waa a GABA receptor modulating steroid antagonist iyo 11-betahydroxysteroid dehydrogenase type 1 (11β-HSD1)…

Product Description

Astaamaha Aasaasiga ah

Product Name Allopregnanolone
CAS Number 516-55-2
Formula kelli C21H34O2
Miisaanka Nooca 318.5
Isku mid ahaanshaha NSC-97078; U-0949; UC-1010; NSC97078; U0949; UC1010; NSC 97078; U 0949; UC 1010; Isopregnanolone; Allopregnanolon; Sepranolone; 516-55-2; 5alpha-uurka-3beta-ol-20-mid
Imaanshaha budo White
Kaydinta iyo Isticmaalka Qalalan, madow iyo 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo) ama -20 C muddo dheer (bilo illaa sannado).

 

Sharaxa Allopregnanolone

Allopregnanolone, oo sidoo kale loo yaqaan Sepranolone iyo Isopregnanolone, waa a GABA receptor modulating steroid antagonist iyo 11-betahydroxysteroid dehydrogenase type 1 (11β-HSD1). Sepranolone waa dhisme neerfaha awood badan leh, oo si dabiici ah loogu soo saaro jirka, kaasoo wax ka beddala saameynta Allopregnanolone (ALLO). ALLO waa neurosteroid xoog leh oo ku lug leh culeys-iyo xaalado laxiriira qasab oo udhaxeeya Tourette ilaa OCD, PTSD, khamaar qasab ah, balwado, PMDD, Madax-xanuun Migreyn.

 

Mashruuca Allopregnanolone ee Waxqabadka

Isdhexgalka muruqyada

Allopregnanolone waa uur-ku-joogsasho uur-jiifa oo uurjiif ah. Waxaa laga sameeyaa progesterone, waana qaab wanaagsan oo loo yaqaan 'allosteric modulator' ee ficilka γ-aminobutyric acid (GABA) ee GABAA receptor. Allopregnanolone wuxuu leeyahay saameyn la mid ah tan kuwa kale ee wax ka beddelaya astaamaha wanaagsan ee waxqabadka GABA ee soo-dhoweynta GABAA sida benzodiazepines, oo ay ku jiraan anxiolytic, sedative, iyo anticonvulsant activity. Si habsami leh u soo saaray allopregnanolone wuxuu ku shaqeeyaa doorka neerfisiolojiyada iyadoo si fiican loo hagaajinayo soo-dhoweynta GABAA iyo wax ka beddelka ficillada dhowr qaab-dhismeedyo isku-dhafan oo wanaagsan iyo agonistayaasha GABAA.

Allopregnanolone wuxuu u shaqeeyaa sidii qaab-dhismeedka allosteric wanaagsan ee wanaagsan ee soo-dhoweynta GABAA. In kasta oo allopregnanolone, sida kuwa kale ee neurosteroid-ka ee xannibaadda ah sida THDOC, ay si togan wax uga beddeleyso dhammaan qaababka soo-dhoweynta GABAA, is-beddelkaas ay ku jiraan δ subunits-ka ayaa muujinaya awoodda ugu weyn. Allopregnanolone sidoo kale waxaa lagu ogaadey inuu u dhaqmayo sidii qaab-dhismeedka wanaagsan ee allosteric ee qalabka 'GABAA-ρ', in kasta oo saameynta ficilkani aanu caddayn. Marka lagu daro ficilkeeda ku saabsan soo-dhoweynta GABA, allopregnanolone, sida progesterone, waxaa loo yaqaanaa inuu yahay modulator xun oo allosteric ah oo ka mid ah soo-dhoweeyeyaasha nACh, sidoo kale wuxuu u muuqdaa inuu u dhaqmayo sidii modulator xun oo allosteric ah oo 5-HT3 receptor ah. Oo ay la socdaan neurosteroid-ka kale ee xanibaada, allopregnanolone wuxuu umuuqdaa mid wax yar ama aan wax qabad ah ka haynin kanaallada kale ee ional-gated gion, oo ay kujiraan NMDA, AMPA, kainate, iyo glycine receptors.

 

Saamaynta lidka diiqada

Habka ay neurosteroid-ka loo yaqaan 'GABAA receptor PAMs' sida brexanolone u leeyihiin saameyn liddi ku ah antidepressant lama yaqaan. Daawooyinka kale ee loo yaqaan 'GABAA receptor PAMs', sida benzodiazepines, looma maleynayo inay yihiin antidepressants mana laha waxqabad la xaqiijiyay, in kasta oo ay takhaatiirtu u qoraan Alprazolam niyad jab hore. Neurosteroid GABAA receptor PAMs waxaa lagu yaqaan inay la falgalaan soo-dhoweeyeyaasha GABAA iyo dadka ka hooseeya si ka duwan benzodiazepines. Tusaalooyin ahaan, GABAA receptor-awood leh neurosteroids ayaa laga yaabaa inay doorbidaan bartilmaameedka δ subunit-ku jira qaboojiyeyaasha GABAA, waxayna xoojinayaan labadaba tonic iyo phasic inhibition oo ay dhexdhexaadinayaan GABAA reseptors. Waxa kale oo suurtogal ah in neurosteroid-yada sida allopregnanolone ay u dhaqmi karaan bartilmaameedyo kale, oo ay ku jiraan qaboojiyeyaasha xinjiraha progesterone, T-nooca kalsiyum-gaaska ku shaqeeya, iyo kuwa kale, si loo dhexdhexaadiyo saamaynta lidka diiqadda.

 

Codsiga Allopregnanolone

Allopregnanolone waa steroid si dabiici ah loo soo saaray oo maskaxda ka shaqeeya. Daawad ahaan, waxaa lagu iibiyaa magaca Zulresso waxaana loo isticmaalaa in lagu daaweeyo murugada umusha kadib. Waxaa loo isticmaalaa cirbadeynta xididka mudo ka badan 60 saacadood kormeer caafimaad.

Dhibaatooyinka soo raaca ee 'Allopregnanolone' waxaa ka mid noqon kara suuxdin, hurdo, af qalalan, hilaac kulul, iyo miyir beelid. Waa neurosteroid waxayna u shaqeysaa sidii qaab wax ku ool ah oo loo yaqaan 'allosteric modulator' ee qalabka 'GABAA receptor', oo ah bartilmaameedka ugu weyn ee bayooloji ee ka hortagga neurotransmitter γ-aminobutyric acid (GABA).

Allopregnanolone waxaa loo ansixiyay adeegsi caafimaad gudaha Mareykanka sanadka 2019. Maamulka Cuntada iyo Dawooyinka ee Mareykanka (FDA) wuxuu u arkaa inay tahay daawo heer-koowaad ah. Waqtiga maamulka dheer, iyo sidoo kale kharashka daaweynta hal-mar ah, waxay dhalisay walaac ku saabsan helitaanka dumar badan.

 

Tixraaca

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