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Alfaxalone

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Alfaxalone waa molecule steroid firfircoon oo leh sifooyin suuxdin guud. Alfaxalone waxaa kiimiko ahaan loogu sifeeyey 3-α-hydroxy-5-α-uurka-11, 20-dione, oo wuxuu leeyahay culeys kelli ah 332.5 .XNUMX

Product Description

Astaamaha Aasaasiga ah

Product Name Alfaxalone
CAS Number 23930-19-0
Formula kelli C21H32O3
Miisaanka Nooca 332.48
Isku mid ahaanshaha Alphaxalone;

Alfaxalone;

23930-19-0;

5alpha-uurka-3alpha-ol-11,20-dione;

Alfaxalonum.

Imaanshaha budo White
Kaydinta iyo Isticmaalka Ku kaydi heerkulka qolka la xakameeyay -20 ° C

 

Sharraxaadda Alfaxalone

Alfaxalone waa molecule steroid firfircoon oo leh sifooyin suuxdin guud. Alfaxalone waxaa kiimiko ahaan loogu sifeeyey 3-α-hydroxy-5-α-uurka-11, 20-dione, wuxuuna leeyahay culeys molikal ah 332.5. Farsamaynta aasaasiga ah ee tallaalka suuxdinta ee alfaxalone waa wax ka beddelidda xuubka unugyada neerfaha ee loo yaqaan 'chloride ion transport', oo ay sababtay ku xirnaanta alfaxalone oo loo yaqaan 'GABAA (gamma-aminobutyric acid) receptors dusha sare.

 

Nidaamka Alfaxalone ee waxqabadka

Alfaxalone wuxuu soo saaraa miyir la'aan isagoo ku shaqeynaya gamma aminobutyric acid subtype A (GABAA) reseptors ee habka dhexe ee neerfaha (CNS). Raawiyeyaashani waa kanaallada ionotropic ligand-gated, GABA-na waa isku-xidhka udhaxeeya jirka. GABA waa neurotransmitter gudbiyaha ugu weyn ee CNS. Ka dib marka soo-dhoweyaha la hawlgeliyo, kanaalka ayaa furmaya isla markaana dhiirrigelinaya ka-qaadista koloriinta unugga, taasoo keeneysa hyperpolarization-ka xuubka postsynaptic. Isugeynta hoose, alfaxalone wuxuu si wanaagsan u habeeyaa koloriin hada socota kanaalka chloride; laakiin heerarka sare, waxay u shaqeysaa sidii agabiste GABA, si la mid ah barbiturates. Natiijada ugu dambeysa waa suuxdin qotodheer ama suuxdin suuxdin, iyadoo kuxiran qiyaasta iyo dariiqa maamulka.

 

Codsiga Alfaxalone

Alfaxalone, oo sidoo kale loo yaqaan alphaxolone ama alphaxalone oo loo adeegsado magaca ganacsiga Alfaxan, waa steroid neuroactive iyo dawada suuxdinta guud ee loo isticmaalo eeyaha iyo bisadaha. Waxaa loo isticmaali karaa inuu yahay wakiilka soo-kicinta ama suuxdinta guud.

 

Faa'iidooyinka & Qasaaraha Alfaxalone

  • Faa'iidada:

Alfaxalone wuxuu sababa isbedel yar oo ku yimaada wax soo saarka wadnaha ama cadaadiska dhiigga marka qiyaaso caafimaad oo laxiriira la siiyo bukaanada caafimaadka qaba. Alfaxalone wuxuu leeyahay tixraac sare oo daaweyn ah, waa jilitaan gaaban, oo aan qallalanayn. Astaamahani waxay ka dhigayaan alfaxalone mid ku habboon in loo isticmaalo sidii wakiilka soo-kicinta ama bixinta suuxdinta la isku duro.

Alfaxalone sidoo kale waxaa loo maamuli karaa si murqo leh, sidaas darteed waxaa loo isticmaali karaa in lagu dajiyo bukaanada aan la shaqeyn karin. Marka alfaxalone loo isticmaalo in lagu dajiyo bukaan socodka qiyaasta daawadu waa 1-3mg / kg IM waxaana badanaa lagu qaataa daawada loo yaqaan 'opioid' ee loogu talagalay suuxinta ugu fiican.

Marka alfaxalone loo adeegsado qalliinka qalliinka eey-yar-yar ayaa eydu aad u feejignaan badan yihiin oo si xawli leh ugu sarreeyaan dhibcaha AGPAR marka la barbar dhigo propofol.

 

  • Qasaaraha:

Alfaxalone wuxuu sababaa qiyaasta niyadjabka neefsashada ee ku tiirsan, iyadoo ay u badan tahay inuu ku dhaco apnea ka dib duritaanka degdegga ah ee IV. Diyaar u noqo intubate, siiso taageero oksijiin, iyo hawo marka aad isticmaaleyso alfaxalone midkood indho-indheyn ama dajin.

Maamulka xad-dhaafka ah ee alfaxalone wuxuu sababi karaa qiyaasta niyadjabka wadnaha iyo xididdada dhiigga, iyadoo hoos u dhac weyni ku yimaadda soo saarista wadnaha iyo cadaadiska dhiigga labadaba. Qiyaasta alfaxalone waa in si taxaddar leh loogu qoraa bukaanada yareeyay keydka wadnaha ama aan hemodynamically degganeyn.

Alfaxalone ma bixiyo wax xanuun baabiin ah, sidaa darteed waa in loo adeegsadaa iyada oo lala kaashanayo opioid ku habboon hababka xanuunka.

Marka alfaxalone loo maamulo si mug leh mugga cirbadeynta wey weynaan kartaa, taasoo sababi karta xanuun ku dhaca cirbadeynta. Muga weyni wuxuu maamulka ka dhigi karaa mid caqabad ku ah marka uu jiro daaqad kooban oo la isku duro iyada oo ay ugu wacan tahay dabeecadda bukaanka. Maamulka Alfaxalone wuxuu sababi karaa dib u soo kabasho liidata oo lagu garto heerar kala duwan oo foorasho, cod bixin, iyo / ama myoclonus.

 

Tixraaca

[1] Whittem T, Pasloske KS, Heit MV iyo al. (2008) Farmashiyada iyo farmasokodimikada alfaxalone ee bisadaha ka dib markii hal iyo dhowr maamul oo xididdada loo yaqaan 'Alfaxan' laga qaato daawooyinka iyo daawooyinka supraclinical. J Vet Pharmacol Ther 31 (6), 571-579.

[2] Ferre PJ, Pasloske K, Whittem T iyo al. (2006) Plasma pharmacokinetics of alfaxalone eeyaha ka dib markii bolus xidid ku ah Alfaxan-CD. Vet Anaesth Analg 33, 229-236.

[3] Muir W, Lerche P, Wiese A et al. (2009) Saamaynta wadnaha iyo daawada suuxdinta ee qiyaasaha daaweynta iyo supraclinical ee alfaxalone ee bisadaha. Vet Anaesth Analg 36, 42-54.

[4] Clarke KW, Trim CM, Hall LW, eds. (2014). "Cutubka 15aad: Suuxdinta eeyga". Suuxdinta xoolaha (11aad ed.). Oxford: WB Saunders. bogga 135-153.

[5] Varga M (2014). "Cutubka 4aad: Suuxdinta iyo Analgesia". Buugga Buugga Daawada Bakeylaha (tirsiga 2aad.). Butterworth-Heinemann. bogga 178-202.

[6] Nieuwendijk H (Maarso 2011). “Alfaxalone”. Kooxda Taageerada Suuxdinta & Xanuunada Xoolaha. Dib loo soo celiyey July 14, 2017.

[7] Zeltzman P (Nofeembar 17, 2014). “Waa maxay sababta maamulida Alfaxalone ay ugu baahan tahay xoogaa waxbarasho ah”. Warka Tababarka Caafimaadka Xoolaha. Dib loo soo ceshay July 14, 2017.