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Afatinib

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Budada Afatinib, oo lagu iibiyo magaca magaca Gilotrif iyo kuwa kale, waa daawo loo isticmaalo in lagu daaweeyo unugyada unugyada yar yar ee kansarka sanbabada (NSCLC) .Waxaa iska leh qoyska daawada tyrosine kinase inhibitor, waxaana lagu qaataa afka.

Product Description

Astaamaha Aasaasiga ah

Product Name Budada Afatinib
CAS Number 439081-18-2
Formula kelli C24H25ClFN5O3
Miisaanka Nooca 485.9
Isku mid ahaanshaha Budada Afatinib;

439081-18-2;

850140-72-6;

BIBW2992;

Tovok.

Imaanshaha budada crystalline White
Kaydinta iyo Isticmaalka Ku keydi heerkulka qolka oo ka fog kuleylka iyo qoyaanka badan.

 

Tilmaanta budada Afatinib

Budada Afatinib, oo lagu iibiyo magaca magaca Gilotrif iyo kuwa kale, waa daawo loo isticmaalo in lagu daaweeyo unugyada unugyada yar yar ee kansarka sanbabada (NSCLC) .Waxaa iska leh qoyska daawada tyrosine kinase inhibitor, waxaana lagu qaataa afka.

Budada Afatinib waxaa badanaa loo isticmaalaa in lagu daaweeyo kiisaska NSCLC ee ku jira isbeddellada ku dhaca hiddo-wadaha koritaanka cuncunka epidermal factor (EGFR).

 

Afatinib Powder Mechanism of Action

Sida lapatinib iyo neratinib, budada afatinib waa borotiin kinase inhibitor ah oo sidoo kale si aan macquul aheyn u xakameynaya cunsur ahaaneedka kobaca cuncunka bini'aadamka 2 (Her2) iyo qanjidhada koritaanka cuncunka epidermal factor (EGFR) kinases. Budada Afatinib kaliya maahan firfircoonida ka soo horjeedka isbeddelka EGFR ee lagu bartilmaameedsaday jiilka koowaad ee tyrosine-kinase inhibitors (TKIs) sida erlotinib ama gefitinib, laakiin sidoo kale ka soo horjeedka isbeddelada aan caadiga ahayn ee u adkaysta daawooyinkan. Si kastaba ha noqotee, ma ahan mid firfircoon oo ka soo horjeeda isbeddelka T790M oo guud ahaan u baahan daawooyinka jiilka saddexaad sida osimertinib Sababtoo ah waxqabadkeeda dheeriga ah ee Her2, waxaa lagu baarayaa kansarka naasaha iyo sidoo kale kansarrada kale ee EGFR iyo Her2.

 

Codsiga Budada Afatinib

Budada Afatinib waxay heshay ogolaansho sharci ah oo loogu talagalay daaweynta daaweynta kansarka sanbabada ee unugyada yar, in kasta oo ay jiraan cadeymo soo baxaya oo lagu taageerayo isticmaalkiisa kansarrada kale sida kansarka naasaha.

 

Afatinib Powder Side Raadka & Digniinta

Aad u badan (> 10% soo noqnoqoshada)

Shuban (> 90%)

▪ Xanuunka finanka 'Rash / dermatitis'

Om Stomatitis

Ron Paronychia

Ite Rabitaanka cuntada oo yaraada

▪ Sanka ayaa dhiig baxa

Cuncun

Skin Maqaar qallalan

 

Caadi ah (1 - 10% inta jeer)

▪ Fuuqbax, Isbadalada dhadhanka, isha oo qallalan

Yst Cystitis, Cheilitis, Qandho

Nose San duuf / cufan leh

Amount Qadar yar oo potassium ah oo ku jirta dhiiga

Jun Xiidmaha

T Kordhay ALT

T Kordhinta AST

Syndrome Cudurka gacmaha-cagta

As Murqaha muruqyada

▪ Kelyo la'aanta iyo / ama hawlgabka

 

Caadi ah (0.1-1% soo noqnoqoshada)

▪ Cudurka 'Keratitis'

Disease Cudurka sanbabada ee kala-goysyada ah

 

Tixraaca

[1] "Gilotrif (budada afatinib) kiniin, filim lagu duubay". DailyMed. Boehringer Ingelheim Pharmaceuticals, Inc. 18 Oktoobar 2019. La soo celiyey 4 Noofambar 2020.

[2] Spreitzer H (13 Maajo 2008). "Neue Wirkstoffe - Tovok". Österreichische Apothekerzeitung (af Jarmal) (10/2008): 498

[3] Minkovsky N, Berezov A (Diseembar 2008). "BIBW-2992, oo ah laba-qaatayaal tyrosine kinase inhibitor ah oo loogu talagalay daaweynta burooyinka adag". Ra'yiga Hada Kajira Dawooyinka Baarista. 9 (12): 1336–46. PMID 19037840.

[4] "Afatinib Powder". Maamulka Cuntada iyo Dawooyinka ee Mareykanka. 12 Luulyo 2013. [xiriiriyaha dhintay] [5] "Giotrif Afatinib Powder (as afatinib dimaleate)" (PDF). Adeegyada Ganacsi ee TGA. Boehringer Ingelheim Pty Limited. 7 Nofeembar 2013. La soo celiyey 28 Janaayo 2014.

[6] Vavalà T (2017). "Doorka budada afatinib ee daaweynta qaaxada sambabada ee unugyada kansarka leh". Farmashiistaha Caafimaadka. 9: 147–157. doi: 10.2147 / CPAA.S112715. PMC 5709991. PMID 29225480.