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EUK-134 (81065-76-1)

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EUK-134 waa xarun antioxidant leh superoxide dismutase iyo dhaqdhaqaaqa catalase ee noocyada oxidative sida peroxynitrite, superoxide, iyo hydrogen peroxide.EUK134 waxay soo bandhigtaa waxqabadyada antioxidant awood leh, waxayna joojisaa samaynta β-amyloid iyo fibril amyloid ee la xidhiidha (IAPP). Waa qalab farmaajo faa'iido badan u leh horumarinta xeryahooda cusub ee daaweynta cudurka Alzheimers iyo Parkinson iyo nooca 2aad ee sonkorowga.

Product Description

EUK-134 Sifooyinka aasaasiga ah ee budada

Product Name EUK-134
Lambarka CAS 81065-76-1
Isku mid ahaanshaha EUK-134;

SALEN-MN/EUK-134;

Chloro[[2,2′-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]] bis[6-methoxyphenolato-κO]]-manganese.

Formula kelli C18H18ClMnN2O4
Miisaanka Nooca 416.7
Imaanshaha Daal ilaa aad u madow budo brown
milmi Ku milmay 0.1N HCl(aq) iyo DMSO
XEERKA Dhoola-caddeynta [Cl-][Mn+3]12([N]3=CC4=CC=CC(OC)=C4[O-]2)[N](CC3)=CC5=CC=CC(OC)=C5[O-]1
Keydka InChi YUZJJFWCXJDFOQ-GAMUHHASSA-K
Xeerka InChi InChI=1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3/b19-11+,20-12+
kaydinta Xaaladda Qalalan, madow iyo 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo) ama -20 C muddo dheer (bilo illaa sannado).
Codsiga EUK 134 waa kakan salen-manganese, superoxide dismutase mimetic.

 

Tixraaca

[1] Baker, K., Marcus, CB, Huffman, K., iyo al. Mimetics-ka isku-darka ah ee superoxide dismutase/catalase mimetics ayaa difaac u ah daawaynta daahitaanka ee qaabka istaroogga jiirka: Door muhiim ah oo loogu talagalay noocyada ogsijiinta falcelinta ee dhaawaca maskaxda ischaemic. J Pharmacol Exp Ther 284 (1) 215-221 (1998). 2 Rong, Y., Doctrow, SR, Tocco, G., iyo al. EUK-134, oo ah superoxide dismutase synthetic iyo catalase mimetic, waxay ka hortagtaa walbahaarka oksaydhka waxayna yaraysaa neerfaha-neuropathology-ga kainate. Proc Natl Acad Sci USA 96 9897-9902 (1999).

[2] SJ Ophoven iyo al. Guryaha Salen-manganese: Qalab casri ah oo loogu talagalay falanqaynta dariiqyada calaamadaynta intercellular ROS. Ka-hortagga kansarka Res. 2010 Oct;30 (10):3967-79.

[3] P. Failli iyo al. Qalab cusub oo manganese ah oo wax ku ool u ah sida superoxide anion scavenger iyo wakiilka daweynta ee ka hortagga unugyada iyo dhaawaca oksaydhiyaha. J Med Chem. 2009 Nof 26;52 (22):7273-83.

[4] D. Decraene iyo al. A synthetic superoxide dismutase / catalase mimetic (EUK-134) waxay joojisaa firfircoonida waxyeelada xuubabka ee dariiqyada kinase borotiinka firfircoon ee mitogen-ka waxayna yaraynaysaa ururinta p53…. J Maalgelinta Dermatol. 2004 Feb; 122 (2): 484-91.

[5] Y. Rong iyo al. EUK-134, oo ah superoxide dismutase synthetic iyo catalase mimetic, waxay ka hortagtaa walbahaarka oksaydhka waxayna yaraysaa neerfaha-neuropathology-ga kainate. Proc Natl Acad Sci US A. 1999 Aug 17;96(17):9897-902.

[6] S. Bahramikia iyo al. Joojinta islet amyloid polypeptide ama isu geynta amylin ee laba nooc oo manganese-sale ah. Eur J Farmashiyaha. 2013 May 5;707(1-3):17-25.

 

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