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γ-Aminobutyric acid (GABA)

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Gebacna waxaa loo qaadaa afka si looga yareeyo walwalka, hagaajinta niyadda, yareynta astaamaha cudurka 'premenstrual syndrome' (PMS), iyo daaweynta cillad la'aanta feejignaanta (ADHD). Waxaa sidoo kale loo isticmaalaa dhiirrigelinta koritaanka murqaha caatada ah, gubashada dufanka, xasilinta cadaadiska dhiigga, iyo yareynta xanuunka.

Product Description

Astaamaha Aasaasiga ah

Product Name γ-Aminobutyric acid (GABA)
CAS Number 56-12-2
Formula kelli C4H9NO2
Miisaanka Nooca 103.12
Isku mid ahaanshaha 4-aminobutyric acid

4-Aaminobutanoic acid

gamma-aminobutyric acid

Gebacna

56-12-2

Imaanshaha budo White
Kaydinta iyo Isticmaalka Qalalan, madow iyo 0 - 4 C muddo gaaban, ama -20 C muddo dheer.

 

γ-Aminobutyric acid (GABA)Description

γ-aminobutyric acid, ama gamma-Aminobutyric acid, ama GABA, waa madaxa kahortaga neurotransmitter-ka ee nidaamka neerfaha ee bartamaha koritaanka bisil. Doorkeeda aasaasiga ah ayaa yareynaya firfircoonaanta neerfaha ee nidaamka neerfaha oo dhan.

GABA waxaa loo iibiyaa sidii nafaqo ahaan dalal badan. Waxaa dhaqan ahaan loo maleeyay in GABA ka baxsan (oo loo qaatay kaabis ahaan) uusan ka tallaabi doonin xannibaadda maskaxda-dhiigga, hase yeeshee xogta laga helay cilmi-baarista hadda socota waxay muujineysaa inay suurtagal tahay.

 

γ-Aminobutyric acid (GABA) Farsamaynta Waxqabadka

Daawooyinka u dhaqma sida qaabeeyeyaasha allosteric ee GABA receptors (oo loo yaqaan 'GABA analogues ama daawooyinka GABAergic), ama kordhiya qadarka la heli karo ee GABA, sida caadiga ah waxay leeyihiin nasasho, ka-hortag walaac, iyo saameyn ka-hortagga qalalaasaha. Qaar badan oo ka mid ah walxaha hoos ku xusan waxaa lagu yaqaan inay sababaan anterograde amnesia iyo retrograde amnesia.

Guud ahaan, GABA kama talaabo caqabadda maskaxda-dhiigga, in kasta oo meelaha qaarkood ee maskaxda oo aan lahayn caqabad dhiig-maskaxeed wax ku ool ah, sida nukleerka periventricular, ay gaari karaan daroogooyinka sida habka duritaanka ee GABA. Ugu yaraan hal daraasad ayaa soo jeedinaysa in afka lagu maamulo GABA ay kordhiso xaddiga hoormoonka koritaanka aadanaha (HGH). GABA si toos ah loogu mudo maskaxda ayaa lagu soo warramey inay leedahay saameyn kicin iyo xakameyn labadaba soo saarista hoormoonka koritaanka, iyadoo kuxiran cilmiga jir ahaaneed ee qofka. Daawooyinka qaarkood ee loo yaqaan 'GABA' (ex. Picamilon) ayaa loo soo saaray si ay u dhex galaan caqabadda maskaxda iyo maskaxda, ka dibna loogu kala baxo GABA iyo maaddooyinka xambaara hal mar maskaxda gudaheeda.

GABA waxay ku xoojisay catabolism-ka serotonin-ka N-acetylserotonin (horudhaca melatonin) ee jiirka. Waxaa sidaas looga shakisan yahay in GABA ay ku lug leedahay soo saarista melatonin oo markaa laga yaabo inay ku yeelato saameyn sharciyeed hurdada iyo howlaha taranka.

 

γ-Aminobutyric acid (GABA) Codsiga

Gamma-Aminobutyric Acid waa si dabiici ah u dhaca neurotransmitter leh nidaamka neerfaha ee dhexe (CNS). Gamma-aminobutyric acid (GABA), oo laga beddelay madaxa sare ee neurotransmitter glutamate ee maskaxda, wuxuu door ka ciyaaraa nidaaminta kacsanaanta neerfaha isagoo ku xiraya soo dhoweeyaasheeda, GABA-A iyo GABA-B, oo markaa keenaya kanaalka furitaanka, hyperpolarization iyo ugu dambeyntii joojinta neurotransmission.

Gamma-aminobutyric acid waa gamma-amino acid taas oo ah butanoic acid oo leh badalka amino ee kutaala C-4. Waxay leedahay door ahaan molecule calaamadeysan, dheef-shiid kiimikaad bini-aadam ah, metabolis Saccharomyces cerevisiae iyo neurotransmitter ah. Waa gamma-amino acid iyo monocarboxylic acid. Waxay ka soo baxdaa asiidh butyric ah. Waa aashito conjugate ee gamma-aminobutyrate. Waa tautomer ah gamma-aminobutyric acid zwitterion.

 

Faa'iidooyinka γ-Aminobutyric acid (GABA)

Gebacna waxaa loo qaadaa afka si looga yareeyo walwalka, hagaajinta niyadda, yareynta astaamaha cudurka 'premenstrual syndrome' (PMS), iyo daaweynta cillad la'aanta feejignaanta (ADHD). Waxaa sidoo kale loo isticmaalaa dhiirrigelinta koritaanka murqaha caatada ah, gubashada dufanka, xasilinta cadaadiska dhiigga, iyo yareynta xanuunka.

 

Tixraaca

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2, Campagna JA, Miller KW, Forman SA (Maajo 2003). "Farsamooyinka ficillada suuxdinta la neefsaday". N. Engl. J. Med. 348 (21): 2110-24. doi: 10.1056 / NEJMra021261. PMID 12761368.

3, Müller EE, Locatelli V, Cocchi D (Abriil 1999). "Xakamaynta Neuroendocrine ee dheecaanka hoormoonka koritaanka". Physiol. Rev. 79 (2): 511-607. doi: 10.1152 / physrev.1999.79.2.511. PMID 10221989.

4, Awoodaha ME, Yarrow JF, McCoy SC, Borst SE (Janaayo 2008). "Jawaabaha hormoonka koritaanka hordhaca ah ee cunnada GABA ee nasashada iyo jimicsiga ka dib". Daawada iyo Sayniska Ciyaaraha iyo Jimicsiga. 40 (1): 104–10. doi: 10.1249 / mss.0b013e318158b518. PMID 18091016.

5, Balemans MG, Mans D, Smith I, Van Benthem J (1983). "Saamaynta GABA ee soo saarista N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol iyo O-acetyl-5-methoxytryptophol ee qanjirka pineal ee labka Wistar rat". Taranka, Nafaqada, Horumarka. 23 (1): 151-60. doi: 10.1051 / rnd: 19830114. PMID 6844712.

6, Sato S, Yinc C, Teramoto A, Sakuma Y, Kato M (2008). "Is-beddelka galmada ee qaab-dhismeedka 'GABA (A) receptor currant by melatonin in rat gonadotropin-releasing hormone neurons'. J Physiol Sayniska. 58 (5): 317–322. doi: 10.2170 / physiolsci.rp006208. PMID 18834560.

7, Kuriyama K, Sze PY (Janaayo 1971). "Dhiig-maskaxda caqabad ku ah H3-γ-aminobutyric acid xoolaha caadiga ah iyo amino oxyacetic acid". Neuropharmacology. 10 (1): 103–108. doi: 10.1016 / 0028-3908 (71) 90013-X. PMID 5569303.

8, Foster AC, Kemp JA (Febraayo 2006). "Daaweynta" Glutamate- iyo GABA-based CNS ". Farm Opin Pharmacol. 6 (1): 7-17. doi: 10.1016 / j.coph.2005.11.005. PMID 16377242.