N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

AASraw is with synthesis and production ability from gram to mass order of  N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide powder (CAS 681136-29-8) , under CGMP regulation and trackable quality control system.

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder waa HOL a phenyl piperazinyl kuwaas oo qaab-dhismeedka waa ka carbamates alkyl iyo Alfa-Keto xeryahooda heterocyclic kala duwan iyo waa inhibitor ah awood iyo xulashada of hydrolase dufan amide acid (FAAH) (IC50s = 34 iyo 33 nm in rat iyo aadanaha, siday u kala horreeyaan) kan kara si looga gudbo xuddunta dhiigga-maskaxda. 1 20 mg / kg, waxay si caqligal ah ugu tiirsan tahay goobta firfircoon ee FAAH iyadoo lagu kala qaybinayo howlaha Hure ee soo saaro aniline iyo carafamat FAAH-poperazinyl.

Product Description

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Nadaafad: ≥99% (HPLC)
micne ah: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Nooca Molecular: C19H19N5OS
Miisaankani waa: 365.459
Maqnaanshaha dhibic: 240.48
Karkarinta: 559.69 ° C at 760 mmHg
mugga: ~ 1.3 g / cm3
Kaydinta Nabadgelyada: Ku kaydi at + 4 ° C
Xalka: DMSO: ≥28mg / mL
Heerka xasaasiga ah: n20D 1.68
Color: A adag crystalline
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
Furaha gudaha: BHBOSTKQCZEAJM-UHFFFAOYSA-N


II. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Isticmaalka budada ee wareega:

1.Name:

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid, JNJ 166101 Powder

2.How waa shaqada N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-Carboxamid Isticmaalka budada?

FAAH-da horay u soo dhigtay JNJ-1661010 waxay soo jeedineysaa is-beddel tartiib ah oo dhexmarta isdhexgalka JNJ1661010 iyo goobta firfircoon, kaas oo lagu dedejiyey heerkul sare. JNJ-1661010 waa aalado, sifo wax-qabad oo ku salaysan dabiiciga ah sida baaritaanka LC-ESI-MS. guraan JNJ-1661010 la phenylthiadiazole ee tunnel-hydrophobic iyo phenylurea ee jeebka hydrophilic of FAAH, JNJ-1661010 (20 mg / ip kg) hakiyo FAAH by ugu yaraan 85% ilaa 4 h ka dib markii kacmaha, taasoo keentay raasamaal ee la egyahay ethanolamides ee maskaxda dareenka. Qiyaasta JNJ-1661010-waxay ku tiirsan tahay kaluunka allodynia oo leh saamiga ugu sareeya ee ku dhawaad ​​90% at 30 min dose-qiyaasta dambe ee jimicsiga Mild Thermal Injury (MTI) iyo qaababka jiir. JNJ-1661010 (20 mg / kg) waxay celinaysaa allodyniya xeeldheer by 60.8% at 30 min min dufanka dareeraha nabar dhaawaca naasaha dareenka. JNJ-1661010 (50 mg / kg ip) waxay muujineysaa saameyn weyn oo ka iman karta hyperegia 30 min dip dioxide ee qaabka carrada carrageenan ee xanuunka inflammatory.
Rats duraa iyada la JNJ-1661010 (20 mg / kg ip) ayaa plasma a Cmax of 26.9 μM ee Tmax of 0.75 h iyo Cmax ah ee maskaxda ee 6.04 μM ee Tmax of 2 h. JNJ-1661010 (20 mg / kg ip) wuxuu joojiyaa maskaxda FAAH waxayna sare u qaadeysaa heerarka AEA ee maskaxda maskaxda.

3.Warning on N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid

4. Talooyin dheeraad ah:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

Si aad u dalbato 10grams.
Baadhitaanka xaddiga caadiga ah (1kg gudaheeda) waxaa loo diri karaa saacadaha 12 kadib bixinta.
Nidaam weyn (1kg gudahood) waxaa loo diri karaa maalmaha shaqada 3 ka dib bixinta.

6. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-karbamamoksid Khudbadda budada:

Si aad u ogaato faahfaahinta macaamiisha (CSR) faahfaahinta, tixraacaaga.

7. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-karboksamid Su'aal:

Si loo bixiyo mustaqbalka soo socda.


III. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide budada HNMR


IV. Sida loo iibsado N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-karboksamid ka soo AASraw?

1.To nagula soo xiriir emailkayaganidaamka weydiinta, ama skype onlinewakiil adeegga macaamiisha (CSR).
2.To nuujinta tirada iyo cinwaanka aad weydiisatay.
3.Our CSR waxay ku siin doontaa qiimaha, qiimaha bixinta, nambarka raadinta, siyaabaha gudbinta iyo taariikhda la qiyaasi karo (ETA).
4.Payment ayaa la sameeyaa, alaabtana waxaa loo diri doonaa saacadaha 12 (Si loo dalbado 10kg).
5.Gudbiyadu waxay heleen oo dhiibaan faallooyin.


Tijaabi bartaada sheyga ee aad jeceshahay:

  Sida loo isticmaalo Clinbuterol miisaanka lumitaanka Waa maxay budada nandrolone loo isticmaalo faa'iidooyinka / nandrolone?


Faahfaahin dheeraad ah oo ku saabsan alaabooyinka la xiriirasoo dhawow inaad gujiso halkan.


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