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Nicotinamide chloride riboside

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Product Description

Astaamaha Aasaasiga ah

Product Name Nicotinamide chloride riboside
CAS Number 23111-00-4
Formula kelli C11H15ClN2O5
Miisaanka Nooca 290.7
Isku mid ahaanshaha 23111-00-4

Nicotinamide chloride riboside

Nicotinamide riboside (chloride)

3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride

Daawada Nicotinamide ribose chloride

Imaanshaha budo White
Kaydinta iyo Isticmaalka 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo), ama -20 C muddo dheer (bilo).

 

Nicotinamide riboside chloride Sharaxaad

Nicotinamide Riboside Chloride (NIAGEN) waa nooca cusbada chloride ee nicotinamide riboside (NR) .NR waa qaab cusub oo pyridine-nucleoside ah oo fiitamiin B3 ah oo u shaqeeya horudhac u ah nicotinamide adenine dinucleotide (NAD) ama NAD + .NIAGEN guud ahaan waxaa loo aqoonsan yahay inay tahay amaan (GRAS) gudaha Mareykanka si loogu isticmaalo badeecooyinka cuntada. Nicotinamide riboside chloride waa qaab madadaalo ah oo loo yaqaan 'Nicotinamide riboside' (NR) chloride. Daawada 'Nicotinamide riboside chloride' waxay kordhisaa heerarka NAD [+] waxayna kicisaa SIRT1 iyo SIRT3, iyadoo lagu soo gabagabeynayo dheef-shiid kiimikaad oksaydh ah iyo kahortaga cunno-xumada aan caadiga ahayn ee ay keento cilladaha dheef-shiid kiimikaadka. Budada Nicotinamide riboside chloride waxaa loo isticmaalaa kaabayaasha cuntada.

 

Nidaamka 'Nicotinamide riboside chloride Mechanism of Action'

Nicotinamide Riboside Chloride (NIAGEN) waa nooca cusbada chloride ee nicotinamide riboside (NR). NR waa qaab pyridine-nucleoside oo fitamiin B3 ah oo u shaqeeya sida horudhaca u ah nicotinamide adenine dinucleotide ama NAD +. NR wuxuu xannibayaa xumaanshaha qalliinka lagu gooyay xidid ganglion neurons ex vivo wuxuuna ka ilaaliyaa maqalka luminta maqalka ee jiirka nool. Budada Nicotinamide riboside waxay ka hortagtaa murqaha, neural iyo melanocyte stem cell senescence. Kordhinta dib-u-cusbooneysiinta murqaha ee jiirka ayaa la arkay ka dib daaweynta nicotinamide riboside, taasoo horseedaysa mala-awaal ah inay hagaajin karto dib-u-cusboonaysiinta xubnaha sida beerka, kelyaha, iyo wadnaha. Nicotinamide riboside sidoo kale waxay hoos u dhigtaa gulukoosta dhiigga iyo beerka dufanka leh ee cudurka prediabetic iyo nooca 2 ee noocyada sonkorowga iyadoo laga hortagayo horumarinta cudurka macaanka ee durugsan. Xusuusin: Nicotinamide Riboside chloride waa isku dar α / β.

 

Nicotinamide riboside chloride Codsiga

Budada Nicotinamide riboside chloride waxay ka diiwaangashan tahay lambar CAS 23111‐00‐4 iyo EC lambar 807 820‐5. Magaceeda IUPAC waa 1 - [(2R, 3R, 4S, 5R) ‐3,4 ‐ dihydroxy ‐ 5‐ (hydroxymethyl) oxolan ‐ 2 ‐ yl] pyridin ‐ 1 ‐ ium ‐ 3 ‐ carboxamide; chloride. Qaaciddada molecule ee nicotinamide riboside chloride waa C11H15N2O5Cl, iyo culeyskeeda molikiyuule 290.7 g / mol. Nicotinamide Riboside Chloride (NIAGEN) waa nooca cusbada chloride ee nicotinamide riboside (NR) .NR waa qaab cusub oo pyridine-nucleoside oo ah fitamiin B3 oo u shaqeeya horudhac u ah nicotinamide adenine dinucleotide (NAD) ama NAD +. Jidhku wuxuu ubaahanyahay NAD + inuu si caadi ah ushaqeeyo. Heerarka hoose ee NAD + waxay sababi karaan dhibaatooyin caafimaad. Qaadashada nikotinamide riboside waxay gacan ka geysan kartaa sare u qaadista heerarkan NAD + hooseeya.

 

Faa'iidooyinka Nicotinamide chloride riboside

Nicotinamide riboside Chloride, oo ah firfircoonaan firfircoon oo afka ah NAD +, wuxuu kordhiyaa heerarka NAD + wuxuuna kiciyaa SIRT1 iyo SIRT3. Budada Nicotinamide riboside Chloride waa isha laga helo fitamiin B3 (niacin) isticmaalna budada Nicotinamide riboside Chloride waxay xoojin kartaa dheef-shiid kiimikaadka oksidheer, ka hortagga cunno-xumada dheef-shiid kiimikaadka leh. Nicotinamide riboside Chloride wuxuu yareeyaa garashada garashada ee qaabka jiirka transgenic ee cudurka Alzheimers.

 

Tixraaca

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[2] Bogan KL, Brenner C. Nicotinic acid, nicotinamide, iyo nicotinamide riboside: qiimeyn molikal ah oo ku saabsan NAD + fiitamiinnada horudhaca ah ee nafaqada aadanaha. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Dib u eegid. PubMed PMID: 18429699.

[3] Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation as a cell-intrinsic, darawal evolutionary ee keydinta dufanka: kiimikada iyo caqiidada dheef-shiid kiimikaadka ee wax ka beddelka acetyl-lysine. Crit Rev Biochem Mol Biyol. 2013-Nofeembar-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Dib u eegid. PubMed PMID: 24050258; PubMed Bartamaha PMCID: PMC4113336.

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[5] Sauve AA. NAD + iyo fiitamiin B3: laga bilaabo dheef-shiid kiimikaad ilaa daaweynta. J Pharmacol Exp Ther. 2008 Mar; 324 (3): 883-93. doi: 10.1124 / jpet.107.120758. Dib u eegid. Caawinaad PMID: 18165311.

[6] Kato M, Lin SJ. Xeerka NAD + dheef-shiid kiimikaadka, calaamadeynta iyo ka-qaybinta khamiirka Saccharomyces cerevisiae. Dayactirka DNA (Amst). 2014 Nofeembar; 23: 49-58. doi: 10.1016 / j.dnarep.2014.07.009. Dib u eegid. PubMed PMID: 25096760; PubMed Bartamaha PMCID: PMC4254062.

[7] Cantó C, iyo al. NAD (+) horudhaca nicotinamide riboside wuxuu xoojiyaa dheef-shiid kiimikaadka oksaydhka wuxuuna ilaaliyaa buurnida ay keento cunnada dufanka badan. Qalabka Metab. 2012 Jun 6; 15 (6): 838-47.

[8] Bing Gong, iyo al. Nicotinamide Riboside waxay dib u soo celisaa garashada iyada oo loo marayo sharciyeyn ku saabsan soo-saare soo-dhoweeye-ac Coactivator 1α Nidaamsan β-Secretase 1 Hoos u dhigid iyo Muujinta Muuqaalka 'Mitochondrial Gene' ee Noocyada Mouse ee Alzheimer. Gabowga Neurobiol. 2013 Juun; 34 (6): 1581-8.

[9] Collin D Heer, iyo al. Coronavirus iyo Muujinta PARP Muujinta Nidaamka NAD Metabolome: Qeyb Waxqabad La Qaban Karo Oo Ka Mid Ah Xasaanadda Dhalashada. bioRxiv. 2020 Abriil 30; 2020.04.17.047480.